PSB 603 – a known selective adenosine A2B receptor antagonist – has anti-inflammatory activity in mice

A2B adenosine receptors are present in a wide spectrum of tissues, especially on cells the immune system. Since these particular have lowest, all receptor subtypes, affinity for they believed to play special role immunological processes associated with elevated levels such as inflammation. The aim this preliminary study was determine potential anti-inflammatory properties compound PSB-603, potent and selective antagonist, two different experimental models local systemic In model inflammation induced by carrageenan administration paw edema measured using pletysmometer. Additionally, C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-?) reactive oxygen species (ROS) were determined inflamed paw. Using mouse peripheral intraperitoneal (ip) zymosan A, influence antagonist infiltration neutrophils into peritoneum its effect plasma CRP, TNF-?, IL-6 investigated. results showed that PSB-603 administered at dose 5 mg/kg b.w. ip significantly reduced both tested models. Particularly, it decreased inflammatory cytokines IL-6, TNF-? ROS decreasing leukocytes. latter model, no statistically significant difference observed CRP level between control group without which has been treated compound. Thus, may indicate activity antagonists